XmAb942 (Xtend™ TL1A)
Novel high-potency anti-TL1A antibody designed for extended half-life, in Phase 1 development for the treatment of patients with IBD
XmAb942 is a monospecific anti-TL1A antibody, utilizing Xencor’s Xtend™ Fc Domain and proprietary Fc silencing technology, with potentially class-leading potency, and is under development for patients with inflammatory bowel diseases (IBD). The two most common forms of IBD are Crohn’s disease and ulcerative colitis.
Xencor announced positive interim data from the first-in-human study of XmAb942 in healthy volunteers in April 2025 and expects to begin a Phase 2 study in participants with moderate to severe active ulcerative colitis in the second half of 2025. (R&D Update, April 29, 2025)